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anygui
The goal of this project is to create an easy-to-use, simple, and generic module for making graphical user interfaces in Python. [Open Source, MIT license]

FXPy
Provides an interface to the FOX GUI library. [Open Source, LGPL]

wxPython
A popular cross-platform Python GUI toolkit for Windows and Unix with native look and feel on each platform. [Open Source, LGPL]

Tix
The Tk Interface eXtension is a set of GUI components that enhance the appearance and functionality of your Tkinter applications. [Open Source, BSD-like]

Tix Applications Framework
Tixapps applications are a suite of development applications that run with Tk/Tcl or Python using the Tix widget set. Applications currently included are: tixinspect - an inspector for Tix/Tk applications; tixdebug - a debugger to work with tixinspect; and tixinfo - an info browser for GNU documentation.

Pmw
Python meta widgets is a toolkit for building high-level compound widgets in Python using the Tkinter module. [Open Source, MIT license]

Python X Library
Pure Python interface to X Window system. [Open Source, GPL]

PythonCard
A software construction kit built in, and using, Python. Its purpose is to allow you to easily and quickly build graphical applications. [Open Source, Python license]

SpecTix GUI Builder
SpecTix provides a development environment to build applications with graphical user interfaces that run on multiple platforms with multiple languages, including Tcl, Python and Ruby.

PyQt
Contains Python bindings for the Qt GUI toolkit. [Open Source, BSD-like]